This module explores the importance of treating newborns, especially those affected by Neonatal Opioid Withdrawal Syndrome (NOWS) and Neonatal Abstinence Syndrome (NAS), with compassionate, evidence-based care. Learners will examine the risks of infant isolation and the benefits of bonding, comfort, and parental involvement. The module highlights best practices such as room-sharing, skin-to-skin contact, responsive feeding, and the “6 S’s” soothing techniques. Participants will learn how to assess and support infants’ ability to eat, sleep, and be consoled, and how to apply ESC (Eat, Sleep, Console) best practices. The module also addresses care strategies when family is unavailable, emphasizing that every baby deserves nurturing and connection. By the end, learners will be equipped to deliver relationship-based care that supports both infants and families.